By Hannah Stottlemyer

Faculty Mentor: Dr. O'Dell

Abstract

We investigated the expression of TOB2 in the hippocampus. Using female mice as models, we socially isolated them to serve as a chronic social stressor. TOB2 has an anti-proliferative effect and negatively regulates a gene expression signaling pathway. After sacrificing the mice, extracting the hippocampus, and isolating the RNA, we performed a qPCR to quantify the expression of TOB2. We compared qPCR results with Corticosterone (CORT) expression, as CORT is a standard measure of stress. Female mice in social cages served as the control group.