By John Conrad Tan

Faculty Mentor: Dr. Parrish Waters, Dr. Ginny Morriss

Abstract

The effect of exercise on brain-derived neurotrophic factor (BDNF) expression in mice is a topic of interest due to its potential implications for cognitive function. This study aimed to investigate how exercise influences BDNF expression in the hippocampus, a brain region crucial for learning and memory. Twelve female CD-1 mice were divided into two groups: exercised (EX) and sedentary (SED). The EX group had access to running wheels, while the SED group did not. After five weeks, mice underwent euthanization to assess hippocampal function. Tissue samples were collected, and BDNF levels were quantified using qPCR. Statistical analysis revealed a significant increase in hippocampal BDNF expression in the EX group compared to the SED group (p < 0.05). These findings suggest that exercise promotes BDNF expression in the hippocampus, potentially enhancing cognitive function. Further research in this area may provide valuable insights into the molecular mechanisms underlying the cognitive benefits of physical activity.